Regularly read XKCD, Penny Arcade, The Trenches, Virtual Shackles, Questionable Content, Oglaf, Octopus Pie, and the newly rebooted Fanboys.
Bittersweet Candy Bowl is my secret shame, although the authors Sonic comic is pretty nice too.

I used to read an absolute tonne of webcomics, but over the last year or so I’ve managed to trim the list down to 14, and 2 of those don’t update very often. Here’s what’s currently in my RSS feeds.

Order of the Stick – http://www.giantitp.com/Comics.html
Dr. McNinja – http://drmcninja.com/
Dumbing of Age – http://www.dumbingofage.com/
Goblins – http://www.goblinscomic.com/
Nedroid – http://nedroid.com/
Oglaf! – http://oglaf.com/
Punks and Nerds – http://brucemanhero.com/
Saturday Morning Breakfast Cereal – http://www.smbc-comics.com/
Sexy Losers – http://sexylosers.com/
Shortpacked! – http://www.shortpacked.com/
Super Effective – http://www.vgcats.com/super/
The Trenches – http://trenchescomic.com/
Thrillbent comics – http://www.thrillbent.com/
XKCD – http://xkcd.com/

My personal favourites from the bunch are Goblins, Dr. McNinja, Oglaf and Saturday Morning Breakfast Cereal. Yeah, I tend to go for the funnies.

Frustrating. Got signed out and lost my post. Second try… EDIT: Success!

Anyone else read What the Birds Know? It’s actually really good, and heavily cliff-hangery with art that is gorgeous and painfully detailed. They’re also kind of asking for more readers, and, after ten years, I figured, “Yeah, more people should know about it.”

That said, their website url is, unfortunately, rather strange and hard to remember. That might have something to do with it.

In addition to that one, I read:

Weregeek
Goblins
Gastrophobia
Gunnerkrigg Court
Friendship is Dragons
Order of the Stick
Erfworld
Yet Another Fantasy Gamer Comic
Rusty and Co.
Darths & Droids
Dr. McNinja (this one’s ending, soon!)
Schlock Mercenary
Sluggy Freelance
Captain SNES
XKCD (and the What-If… spin-off)
Manly Guys Doing Manly Things
Avengers: Roll for Initiative!
Kill Six Billion Demons

Although I’ve checked it often enough, considering No Rest For the Wicked has not updated in two years, I’m presuming that (at present) it’s dead.

Those are my most consistent reads. Occasionally, I’ll go for The Wotch or some other comic that doesn’t update much anymore, or a few who do that I just don’t follow as faithfully, but those are (obviously) more rare on my “check ’em” list.

EDIT: For clarity and to add two I’d lost in remaking the post